点击上方“转化医学网”订阅我们！

干货 | 靠谱 | 实用

第 26 弹

Title：Study shows vitamin D3 could help heal or prevent cardiovascular damage

A new study conducted by Ohio University scientists suggests that a little more sunlight might help restore damage to your cardiovascular system.

The study shows that vitamin D3 – which is made by the body naturally when skin is exposed to the sun – can significantly restore the damage to the cardiovascular system caused by several diseases, including hypertension, diabetes and atherosclerosis. Vitamin D3 supplements are also available over the counter.

The study, by Marvin and Ann Dilley White Chair and Distinguished Professor Dr. Tadeusz Malinski and two graduate students, Alamzeb Khan and Hazem Dawoud, has been published in the International Journal of Nanomedicine.

"Generally, vitamin D3 is associated with the bones. However, in recent years, in clinical settings people recognize that many patients who have a heart attack will have a deficiency of D3. It doesn't mean that the deficiency caused the heart attack, but it increased the risk of heart attack," Malinski said. "We use nanosensors to see why vitamin D3 can be beneficial, especially for the function and restoration of the cardiovascular system."

Malinski's team has developed unique methods and systems of measurements using nanosensors, which are about 1,000 times smaller in diameter than a human hair, to track the impacts of vitamin D3 on single endothelial cells, a vital regulatory component of the cardiovascular system. A major discovery from these studies is that vitamin D3 is a powerful stimulator of nitric oxide (NO), which is a major signaling molecule in the regulation of blood flow and the prevention of the formation of clots in the cardiovasculature. Additionally, vitamin D3 significantly reduced the level of oxidative stress in the cardiovascular system.

Most importantly, these studies show that treatment with vitamin D3 can significantly restore the damage to the cardiovascular system caused by several diseases, including hypertension, atherosclerosis, and diabetes, while also reducing the risk of heart attack. These studies, performed on cells from Caucasian Americans and African Americans, yielded similar results for both ethnic groups.

"There are not many, if any, known systems which can be used to restore cardiovascular endothelial cells which are already damaged, and vitamin D3 can do it," Malinski said. "This is a very inexpensive solution to repair the cardiovascular system. We don't have to develop a new drug. We already have it."

These studies, performed at Ohio University, are the first to identify the molecular mechanism of vitamin D3-triggered restoration of the function of damaged endothelium in the cardiovasculature. While these studies were performed using a cellular model of hypertension, the implication of vitamin D3 on dysfunctional endothelium is much broader. The dysfunction of endothelium is a common denominator of several cardiovascular diseases, particularly those associated with ischemic events.

Therefore, the authors suggest that vitamin D3 may be of clinical importance in the restoration of dysfunctional cardiac endothelium after heart attack, capillary endothelium after brain ischemia (stroke), hypovolemia, vasculopathy, diabetes and atherosclerosis. This suggestion is strongly supported by several clinical studies which indicate that vitamin D3 at doses higher than those currently used for the treatment of bone diseases, may be highly beneficial for the treatment of the dysfunctional cardiovascular system.

"Professor Malinksi has an international reputation for outstanding and innovative research related to the cardiovascular system," Ohio University Dean of Arts and Sciences Robert Frank said. "This latest work is yet another example of his impact on this field."

投稿邮箱：wangjiani@360zhyx.com

投稿规则

1.本次活动为自愿参加，关注每日文章推送即可，每周一、周三、周五发布翻译稿件，周二、周四、周六进行翻译文章刊登；每篇文章投稿时间为2天，周一的推送截止翻译日期为当周周三，以此类推，节假日顺延投稿时间

2.投稿形式：以word文字版为准，文件名为：第几弹+姓名 。以附件形式发送至投稿邮箱。

3.参与活动均可获得转化医学网小礼品（价值30元左右）1份，被录取的文章将得到100元/篇的稿酬；您可在邮件正文或附件中留下地址号码领取礼物，因为礼物的邮寄可能需要一段时间，请您耐心等待

4.投稿文件转化医学网编辑部收到后，会进行审核，我们会在2~3个工作日内给与回复

5.得到文稿被录用邮件回复的作者可添加转化医学网内容部同事微信领取相应微信红包

6.本次活动最终解释权归转化医学网所有

END

活动

推荐

转折点——生物医药招聘第一平台